The Best Supplement Stacks for 2026
What the top longevity experts like Bryan Johnson and Dr. Berg are prioritizing this year.
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The longevity landscape has shifted from “take everything” to precision stacking.
Here’s the gold standard for 2026.
The Foundation (Non-Negotiables)
Every expert agrees on these pillars.
💊 Vitamin D3 + K2 (MK-7)
| Aspect | Details |
|---|---|
| Why | Immune modulation, arterial health |
| 2026 Update | K2 even more critical for preventing soft tissue calcification |
| Dosage | 5,000 IU D3 + 100mcg K2 daily |
💊 Magnesium Glycinate
| Aspect | Details |
|---|---|
| Why | Sleep quality, stress resilience |
| Dosage | 400mg before bed |
💊 Omega-3 (High EPA)
| Aspect | Details |
|---|---|
| Why | Brain health, inflammation control |
| 2026 Update | Focus on EPA for mental clarity |
| Target | >2g EPA daily |
The Longevity Tier (Advanced)
💊 NMN (Nicotinamide Mononucleotide)
Despite regulatory battles, NMN remains a staple.
| Aspect | Details |
|---|---|
| Protocol | 1g daily with fat (yogurt/olive oil) |
| Verdict | Still the king of NAD+ restoration |
💊 Urolithin A
| Aspect | Details |
|---|---|
| Why | Mitophagy (cleaning old mitochondria) |
| 2026 Update | Significant muscle endurance improvements in 40+ |
| Status | Breakout supplement of the year |
💊 Glycine + NAC (GlyNAC)
| Aspect | Details |
|---|---|
| Why | Glutathione precursor |
| Benefit | Powerful antioxidant that declines with age |
The “Blueprint” Protocol Highlights
Bryan Johnson’s latest updates:
| Supplement | Purpose |
|---|---|
| Micro-dosed Lithium (1mg) | Brain health |
| Hyaluronic Acid | Joint and skin health |
| Cocoa Flavanols | Vascular health and cognition |
Note: Always consult with your doctor. What works for a tech billionaire might not work for you.
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Medical Disclaimer: This article is for educational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before starting any supplementation regimen.
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